High levels of IB6 are often found in NSCLC, making it a good target for treatment. A preclinical study found that in lung cancer, IB6 was correlated with interleukin-8 levels and promoted cancer cell ...

Pfizer's integrin αvβ6-targeting Antibody-Drug Conjugate (ADC) candidate, Sigvotatug Vedotin (PF-08046047, also known as SGN-B6A), has progressed to Phase III clinical trials for PD-L1 high-expressing ...

Insulin-like growth factor binding protein-2 (IGFBP-2) is significantly increased in the serum of patients with malignant gliomas. High plasma IGFBP-2 levels are correlated with poor prognosis in ...

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC) is the sixth ...

The α1β1 collagen receptor is only present in a few epithelial cell types. In the intestine, it is specifically expressed in proliferating crypt cells. This integrin has been reported to be involved ...