Thirty years after its discovery, scientists are eyeing leptin with renewed interest, for everything from weight loss drug ...

A growing body of research suggests the brain plays a central role in diabetic ketoacidosis, opening the possibility of treating type 1 diabetes in an entirely new way.

Leptin is a cell-signalling hormone vital in the regulation of appetite, food intake and body weight. Studies have shown that an absence of leptin in the body or leptin resistance can lead to ...

Numerous laboratory studies involving both animal and human models indicate that weight loss induces changes in leptin, ghrelin and insulin sensitivity, which work to promote weight regain. It is ...

OBJECTIVE: To examine the determinants of plasma leptin levels and leptin resistance in a sample of extremely obese subjects and their relatives. DESIGN and METHOD: We obtained plasma leptin values on ...

Twenty years after the hormone leptin was found to regulate metabolism, appetite, and weight through brain cells called neurons, Yale School of Medicine researchers have found that the hormone also ...

Plasma leptin levels were linked with Alzheimer's disease PET pathology in cognitively unimpaired older adults in Korea. Lower baseline leptin was associated with a greater increase in tau over 2 ...

Leptin plays an important role in regulating appetite and body weight. Leptin binds to a form of leptin receptor present in the cells of the hypothalamus. This stimulates an intracellular signalling ...

New research offers insight into leptin, a hormone that plays a key role in appetite, overeating, and obesity. The findings advance knowledge about leptin and weight gain, and also suggest a potential ...

The adipocyte hormone leptin is important in regulating energy homeostasis. Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic ...