The Philadelphia Eagles come in as the NFC East champions, but the Buffalo Bills have work to do to retain their AFC East title when they host this NFL Week 17 matchup. The Eagles (10-5) hit a rough patch and went on a three-game losing skid because of an inconsistent offense but have bounced back to score 60 points in winning their past two games.

Week 16 features huge matchups with the NFL playoffs approaching. Here are the odds, spreads and totals for every game.

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Week 17 features critical matchups with the NFL playoffs approaching. Here are the odds, spreads and totals for every game.

If you’ve ever watched live odds move before your eyes, you know the feeling. A match changes pace, someone gets injured, the crowd rises — and the numbers shift as if they already knew what would happen.