The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which splicing ...

One idea has been that speckles are splicing factories. The splicing reaction would happen inside the speckle, and then the spliced product would leave. “What people found is that’s not what happens,” ...

What are the mechanisms of alternative splicing? Prior to RNA splicing, RNA polymerase II produces pre-mRNA transcripts by transcribing gene sequences into a collection of non-coding introns and ...

A study published in Engineering shows that a protein called U2 small nuclear RNA auxiliary factor 1 (U2AF1), released by ...

Type-II diabetes is a chronic disease caused by insulin resistance due to pancreatic β-cell dysfunction. Mutations in a single gene, HNF1A, which codes for the transcription factor hepatocyte nuclear ...

"Splicing in more complex organisms, like humans, is more complicated than it is in some model organisms like yeast, even ...

In a new study, researchers demonstrate that deregulation of a protein called RBFOX2, involved in RNA splicing, contributes to the progression and metastasis of pancreatic cancer. Pancreatic cancer ...

Study design to create a database of transcripts, called TRAILS (TRAnscriptomic resource of Immune cells using Long-read Sequencing), from different human immune cell subsets and downstream analysis.

Let's Build a Zoo, the adorable DNA-splicing management sim from developer Springloaded Games, will be throwing open its doors and inviting guests to admire its scientifically dubious exhibits from ...