GutOpinion

Deferring first surveillance to 3 years after colorectal ESD is not supported by these data

Qatomah and colleagues conclude that the first surveillance colonoscopy (SC1) after colorectal endoscopic submucosal ...
Gut

Rare cause of epigastric distension and vomiting

A 61-year-old Chinese female was admitted with a 1-week history of epigastric pain. She reported recurrent episodes of mild ...
Gut

Faecal proteases and immune signatures drive subtype-specific enteric neuronal activation in IBS

Background Luminal proteases have been implicated in epithelial barrier dysfunction and visceral hypersensitivity in ...
gut.bmj

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study

Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate ...
gut.bmj

Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer

Correspondence to Professor Dr Patrick Michl, Department of Internal Medicine I, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, Halle D-06120, Germany; patrick.michl{at}uk-halle.de ...
gut.bmj

Transition to quantitative faecal immunochemical testing from guaiac faecal occult blood testing in a fully rolled-out population-based national bowel screening programme

Correspondence to Professor Robert JC Steele, Centre for Research into Cancer Prevention and Screening, University of Dundee, Dundee, Scotland DD1 9SY, UK; r.j.c.steele{at}dundee.ac.uk Objective ...
gut.bmj

Targeting lipid droplets in the management of MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) refers to a spectrum of liver disorders characterised by hepatic steatosis, which most often occurs in the setting of established ...
gut.bmj

Metabolic syndrome, metabolic comorbid conditions and risk of early-onset colorectal cancer

Correspondence to Dr Yin Cao, Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in Saint Louis, Saint Louis, MO 63110, USA; yin.cao{at}wustl.edu ...
gut.bmj

Mortality in biopsy-confirmed nonalcoholic fatty liver disease: results from a nationwide cohort

Objective Population-based data are lacking regarding the risk of overall and cause-specific mortality across the complete histological spectrum of non-alcoholic fatty liver disease (NAFLD). Design ...
gut.bmj

Exploring prognostic indicators in the pathological images of hepatocellular carcinoma based on deep learning

1 Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, ...
gut.bmj

Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men

Objectives Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link between red meat intake and poor cardiometabolic health. We investigated whether gut microbiome could modify ...
gut.bmj

Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas

Objective We aim to unveil the consequences of mutant Gnas R201C expression on phenotype, transcriptomic profile and genomic dependencies. Data are available in a public, open access repository. Bulk ...