Potentially more than 90% of Alzheimer’s disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers. The scientists also found ...

Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular ...

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ Dundee, Scotland, U.K. Division of Biological Chemistry and Drug Discovery, ...

The majority of highly polymorphic genes are related to immune functions and with over 100 alleles within a population, genes of the major histocompatibility complex (MHC) are the most polymorphic ...

This narrative review discusses the genetic determinants of plasma lipoprotein(a) levels and explores the factors that influence interindividual heterogeneity, including single‐nucleotide ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. In this study, the authors attempt to reinvestigate an old ...

Homozygous, or homozygosity, refers to the inheritance of genes from each biological parent. Inheriting faulty genes from both parents can cause a person to develop the associated condition. Genetic ...

Conventional wisdom holds that sexual reproduction evolved because it enables organisms to shuffle, or recombine, different alleles (versions of a gene) in the next generation, producing the genetic ...

Understanding allele frequency is a fundamental concept in population genetics and evolutionary biology. It enables researchers to study how genes are dispersed within populations and how they change ...

While eukaryotic genes typically contain introns with conventional GT-AG boundaries, many nonconventional introns, which lack these boundaries, remain poorly characterized. Our genome-wide analysis ...