C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large role in the immune response. C3a molecules induce responses through the …

Aug 1, 2025 · C3a functions as a potent mediator of inflammation, influencing both innate and adaptive immune responses. It achieves its effects by binding to a specific receptor, the C3a receptor (C3aR), …

C3a complement is defined as a proinflammatory mediator derived from the α-chain of C3 following the activation of the classical and alternative pathways of the complement cascade.

C3a is a small, highly cationic protein derived from the proteolytic cleavage of the alpha chain of C3, a key molecule in the complement system. Its unique structural attributes enable it to function as an …

C3a is an anaphylatoxin that triggers a response by stimulating inflammatory cells to release histamine, enzymes, cytokines and other mediators.

C3a is the smaller fragment that is released into the surrounding fluids. C3a can bind to receptors on basophils and mast cells triggering them to release their vasoactive amines (e.g. histamine). …

In the kidneys, C3aR is primarily expressed on the tubular epithelium and less in glomerular podocytes. C3aR expression is enhanced and the levels of C3a in the plasma and urine are increased in kidney …

Jan 15, 2021 · Is C3a Inflammatory or Anti-Inflammatory? C3a is most commonly seen as inflammatory, alongside its cousin C5a. Indeed, high C3a, in the long run, does worsen chronic inflammation. But …

Sep 15, 2022 · C3a is produced from C3 by the C3 convertase complex, which includes the essential component complement factor D (Cfd). Cfd-knockout mice also show attenuation of right ventricular …

Aug 18, 2020 · In the kidneys, C3aR is primarily expressed on the tubular epithelium and less in glomerular podocytes. C3aR expression is enhanced and the levels of C3a in the plasma and urine …